This plenary session will address the intersection of the social determinants of health, the global COVID-19 pandemic, national HIV, HCV, STI, and LGBTQ healthcare planning efforts, and racial and social justice issues—and the disparate impact on health equity and long-term health outcomes among medically underserved populations. Leaders from health departments, health centers, STI clinics, and community-based organizations will discuss their efforts to advance health equity through the development and implementation of culturally-responsive HIV, HCV, STI, LGBTQ, and now COVID-19 services. A panel discussion will sync these issues and intersections, as well as their collective impact on health outcomes at the individual and population levels, particularly among racial and ethnic minorities and LGBTQ persons.